EC |
2.5.1.146 |
Accepted name: |
3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase |
Reaction: |
geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate |
Other name(s): |
famD2 (gene name) |
Systematic name: |
geranyl-diphosphate:3-[(Z)-2-isocyanoethenyl]-1H-indole geranyltransferase |
Comments: |
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Li, S., Lowell, A.N., Yu, F., Raveh, A., Newmister, S.A., Bair, N., Schaub, J.M., Williams, R.M. and Sherman, D.H. Hapalindole/ambiguine biogenesis Is mediated by a Cope rearrangement, C-C bond-forming cascade. J. Am. Chem. Soc. 137 (2015) 15366–15369. [DOI] [PMID: 26629885] |
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[EC 2.5.1.146 created 2018] |
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