The Enzyme Database

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Accepted name: rRNA small subunit aminocarboxypropyltransferase
Reaction: S-adenosyl-L-methionine + an N1-methylpseudouridine in rRNA = S-methyl-5′-thioadenosine + an N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA
Other name(s): TSR3 (gene name)
Systematic name: S-adenosyl-L-methionine:rRNA N1-methylpseudouridine 3-[(3S)-3-amino-3-carboxypropyl]transferase
Comments: The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3ψ). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC, 2-(3-amino-3-carboxypropyl)histidine synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kotter, P., Lafontaine, D.L., Wohnert, J. and Entian, K.D. Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. Nucleic Acids Res. 44 (2016) 4304–4316. [DOI] [PMID: 27084949]
[EC created 2023]

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