| EC |
2.5.1.157 |
| Accepted name: |
rRNA small subunit aminocarboxypropyltransferase |
| Reaction: |
S-adenosyl-L-methionine + an N1-methylpseudouridine in rRNA = S-methyl-5′-thioadenosine + an N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA |
| Other name(s): |
TSR3 (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:rRNA N1-methylpseudouridine 3-[(3S)-3-amino-3-carboxypropyl]transferase |
| Comments: |
The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3ψ). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC 2.5.1.108, 2-(3-amino-3-carboxypropyl)histidine synthase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kotter, P., Lafontaine, D.L., Wohnert, J. and Entian, K.D. Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. Nucleic Acids Res. 44 (2016) 4304–4316. [DOI] [PMID: 27084949] |
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| [EC 2.5.1.157 created 2023] |
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