The Enzyme Database

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Accepted name: thiamine pyridinylase
Reaction: thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole
For diagram of reaction, click here
Other name(s): pyrimidine transferase; thiaminase I; thiamin hydrolase; thiamin pyridinolase; thiaminase (ambiguous); thiamine pyridinolase; thiamin pyridinylase; thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Systematic name: thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Comments: Various bases and thiol compounds can act instead of pyridine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-35-7
1.  Fujita, A. Thiaminases. Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 389–421. [PMID: 13158184]
2.  Kenten, R.H. The partial purification and properties of a thiaminase from bracken [Pteridium aquilinum (L.) Kuhn] Biochem. J. 67 (1957) 25–33. [PMID: 13471505]
3.  Wittliff, J.L. and Airth, R.L. The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties. Biochemistry 7 (1968) 736–744. [PMID: 4966932]
[EC created 1961, modified 1976, modified 2001]

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