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Your query returned 1 entry. 
Printable version
| EC | 2.5.1.44 | ||||||||
| Accepted name: | homospermidine synthase | ||||||||
| Reaction: | (1) 2 putrescine = sym-homospermidine + NH3 (2) spermidine + putrescine = sym-homospermidine + propane-1,3-diamine |
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| For diagram of reaction, click here | |||||||||
| Glossary: | sym-homospermidine = N1-(4-aminobutyl)butane-1,4-diamine putrescine = butane-1,4-diamine |
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| Other name(s): | putrescine:putrescine 4-aminobutyltransferase (ammonia-forming) | ||||||||
| Systematic name: | putrescine/spermidine:putrescine 4-aminobutyltransferase | ||||||||
| Comments: | The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 76106-84-8 | ||||||||
| References: |
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