ExplorEnz: EC 2.5.1.52

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2.5.1.52

Accepted name:

L-mimosine synthase

Reaction:

O-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate

For diagram of O³-Acetyl-L-serine metabolism, click here

Glossary:

O-acetyl-L-serine = (2S)-3-acetyloxy-2-aminopropanoic acid
L-mimosine = (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid

Other name(s):

O³-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl); 3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase; O³-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase

Systematic name:

O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase

Comments:

Brings about the biosynthesis of L-mimosine in plants of the Mimosa and Leucaena genera. Not identical with EC 2.5.1.51, β-pyrazolylalanine synthase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 93229-75-5

References:

1.	Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. Purification and characterization of β-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris. Phytochemistry 23 (1984) 973–977.
2.	Murakoshi, I., Ikegami, F., Hinuma, Y. and Hanma, Y. Purification and characterization of L-mimosine synthase from Leucaena leucocephala. Phytochemistry 23 (1984) 1905–1908.
3.	Murakoshi, I., Kuramoto, H. and Haginiwa, J. The enzymic synthesis of β-substituted alanines. Phytochemistry 11 (1972) 177–182.
4.	Noji, M., Murakoshi, I. and Saito, K. Evidence for identity of β-pyrazolealanine synthase with cysteine synthase in watermelon: formation of β-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo. Biochem. Biophys. Res. Commun. 197 (1993) 1111–1117. [DOI] [PMID: 8280125]

[EC 2.5.1.52 created 1989 as EC 4.2.99.15, transferred 2002 to EC 2.5.1.52]