ExplorEnz: EC 2.5.1.53

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2.5.1.53

Accepted name:

uracilylalanine synthase

Reaction:

O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate

For diagram of O³-Acetyl-L-serine metabolism, click here

Glossary:

O-acetyl-L-serine = (2S)-3-acetyloxy-2-aminopropanoic acid
3-(uracil-1-yl)-L-alanine = L-willardiine
3-(uracil-3-yl)-L-alanine = L-isowillardiine

Other name(s):

O³-acetyl-L-serine acetate-lyase (adding uracil); isowillardiine synthase; willardiine synthase; 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase; O³-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Systematic name:

O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase

Comments:

The enzyme produces the non-proteinogenic amino acid L-willardiine, which is naturally found in the plants Acacia willardiana, Mimosa pigra, and Pisum sativum (pea). The enzyme from Pisum species also produces L-isowillardiine. Not identical with EC 2.5.1.47 cysteine synthase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 113573-73-2

References:

1.	Ahmmad, M.A.S., Maskall, C.S. and Brown, E.G. Partial-purification and properties of willardiine and synthase activity from Pisum sativum. Phytochemistry 23 (1984) 265–270.
2.	Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I. Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum. Phytochemistry 26 (1987) 2699–2704.
3.	Murakoshi, I., Ikegami, F., Ookawa, N., Ariki, T., Haginiwa, J., Kuo, Y.-H. and Lambein, F. Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants. Phytochemistry 17 (1978) 1571–1576.

[EC 2.5.1.53 created 1990 as EC 4.2.99.16, transferred 2002 to EC 2.5.1.53]