The Enzyme Database

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Accepted name: N-acetylneuraminate synthase
Reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate
For diagram of reaction, click here
Other name(s): (NANA)condensing enzyme; N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating); NeuAc synthase
Systematic name: phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37290-66-7
1.  Blacklow, R.S. and Warren, L. Biosynthesis of sialic acids by Neisseria meningitidis. J. Biol. Chem. 237 (1962) 3520–3526. [PMID: 13971393]
2.  Komaki, E., Ohta, Y. and Tsukada, Y. Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12. Biosci. Biotechnol. Biochem. 61 (1997) 2046–2050. [DOI] [PMID: 9438985]
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