| EC |
2.5.1.57 |
| Accepted name: |
N-acylneuraminate-9-phosphate synthase |
| Reaction: |
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate |
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For diagram of reaction, click here |
| Other name(s): |
N-acetylneuraminate 9-phosphate lyase; N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase; N-acetylneuraminate 9-phosphate synthetase; N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating); sialic acid 9-phosphate synthetase |
| Systematic name: |
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase |
| Comments: |
Acts on N-glycoloyl and N-acetyl-derivatives. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9031-58-7 |
| References: |
| 1. |
Roseman, S., Jourdian, G.W., Watson, D. and Rood, R. Enzymatic synthesis of sialic acid 9-phosphates. Proc. Natl. Acad. Sci. USA 47 (1961) 958–961. [PMID: 13743311] |
| 2. |
Watson, D.R., Jourdian, G.W. and Roseman, S. The sialic acids. 8. Sialic acid 9-phosphate synthetase. J. Biol. Chem. 241 (1966) 5627–5636. [PMID: 5928202] |
| 3. |
Nakata, D., Close, B.E., Colley, K.J., Matsuda, T. and Kitajima, K. Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity. Biochem. Biophys. Res. Commun. 273 (2000) 642–648. [DOI] [PMID: 10873658] |
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| [EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57] |
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