The Enzyme Database

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Accepted name: trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
Reaction: (2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9–11)
For diagram of trans-polycis-polyprenol diphosphate biosynthesis, click here
Systematic name: (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9–11 isopentenyl units)
Comments: Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate. Broad product specificity with the major product being dodecaprenyl diphosphate. Synthesizes even C70 prenyl diphosphate as the maximum chain-length product [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Ambo, T., Noike, M., Kurokawa, H. and Koyama, T. Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca. J. Biosci. Bioeng. 107 (2009) 620–622. [DOI] [PMID: 19447338]
[EC created 2010]

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