ExplorEnz: EC 2.6.1.107

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2.6.1.107

Accepted name:

β-methylphenylalanine transaminase

Reaction:

(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate

Glossary:

(3S)-2-oxo-3-phenylbutanoate = (3S)-β-methyl-phenylpyruvate

Other name(s):

TyrB

Systematic name:

(2S,3S)-3-methylphenylalanine:2-oxoglutarate aminotransferase

Comments:

Requires pyridoxal phosphate. Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Huang, Y.T., Lyu, S.Y., Chuang, P.H., Hsu, N.S., Li, Y.S., Chan, H.C., Huang, C.J., Liu, Y.C., Wu, C.J., Yang, W.B. and Li, T.L. In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-β-methylphenylalanine in glycopeptide antibiotic mannopeptimycin. ChemBioChem 10 (2009) 2480–2487. [DOI] [PMID: 19731276]

[EC 2.6.1.107 created 2014]