The Enzyme Database

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Accepted name: L-aspartate:5-guanidino-3-methyl-2-oxopentanoate transaminase
Reaction: L-aspartate + (3R)-5-guanidino-3-methyl-2-oxopentanoate = oxaloacetate + (3R)-3-methyl-L-arginine
Other name(s): argM (gene name); mrsB (gene name)
Systematic name: L-aspartate:5-guanidino-3-methyl-2-oxopentanoate aminotransferase
Comments: Requires pyridoxal 5′-phosphate. The enzyme, characterized from several bacterial species, participates in the biosynthesis of the rare amino acid (3R)-3-methyl-L-arginine. The enzyme from Streptomyces arginensis also catalyses the activity of EC, L-arginine:2-oxoglutarate transaminase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Braun, S.D., Hofmann, J., Wensing, A., Ullrich, M.S., Weingart, H., Völksch, B. and Spiteller, D. Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93. Appl. Environ. Microbiol. 76 (2010) 2500–2508. [DOI] [PMID: 20190091]
2.  Feng, J., Wu, J., Gao, J., Xia, Z., Deng, Z. and He, X. Biosynthesis of the β-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941. Appl. Environ. Microbiol. 80 (2014) 5021–5027. [DOI] [PMID: 24907335]
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