The Enzyme Database

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Accepted name: alanine transaminase
Reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate
For diagram of reaction, click here and for mechanism, click here
Other name(s): glutamic-pyruvic transaminase; glutamic-alanine transaminase; GPT (ambiguous); alanine aminotransferase; alanine-α-ketoglutarate aminotransferase; alanine-pyruvate aminotransferase; ALT; glutamic acid-pyruvic acid transaminase; glutamic-pyruvic aminotransferase; L-alanine aminotransferase; L-alanine transaminase; L-alanine-α-ketoglutarate aminotransferase; pyruvate transaminase; pyruvate-alanine aminotransferase; pyruvate-glutamate transaminase
Systematic name: L-alanine:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9000-86-6
1.  Dumitru, I.F., Iordachescu, D. and Niculescu, S. Chromatographic purification, crystallization and study of vegetable L-alanine: 2-oxoglutarate-aminotransferase properties. Experientia 26 (1970) 837–838. [PMID: 5452003]
2.  Dumitru, I.F., Iordachescu, D. and Niculescu, S. L-Alanine: 2-oxoglutarate-aminotransferase chromatographic purification and crystallization of the enzyme from seeds of Glycine hispida var Cheepeura. Rev. Roum. Biochim. 7 (1970) 31–44.
3.  Green, D.E., Leloir, L.F. and Nocito, W. Transaminases. J. Biol. Chem. 161 (1945) 559–582. [PMID: 21006939]
4.  Iordachescu, D., Dumitru, I.F. and Corniciuc, M.-T. Comparative biochemical studies concerning L-alanine: 2-oxoglutarate-aminotransferase from the liver and the bile of swines. Rev. Roum. Biochim. 20 (1983) 173–179.
5.  Wilson, D.G., King, K.W. and Burris, R.H. Transaminase reactions in plants. J. Biol. Chem. 208 (1954) 863–874. [PMID: 13174595]
[EC created 1961]

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