| EC |
2.6.1.24 |
| Accepted name: |
diiodotyrosine transaminase |
| Reaction: |
3,5-diiodo-L-tyrosine + 2-oxoglutarate = 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate |
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For diagram of reaction, click here and for reaction mechanism, click here |
| Other name(s): |
diiodotyrosine aminotransferase; halogenated tyrosine aminotransferase; halogenated tyrosine transaminase |
| Systematic name: |
3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase |
| Comments: |
A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-18-5 |
| References: |
| 1. |
Nakano, M. Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria. J. Biol. Chem. 242 (1967) 73–81. [PMID: 4381052] |
| 2. |
Nakano, M. and Danowski, T.S. Thyroid-hormone transaminase and oxidase in rat-kidney mitochondria. Biochim. Biophys. Acta 85 (1964) 18–28. [PMID: 14159298] |
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| [EC 2.6.1.24 created 1972 (EC 2.6.1.25 created 1972, incorporated 1972)] |
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