The Enzyme Database

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Accepted name: diiodotyrosine transaminase
Reaction: 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 4-hydroxy-3,5-diiodophenylpyruvate + L-glutamate
For diagram of reaction, click here and for reaction mechanism, click here
Other name(s): diiodotyrosine aminotransferase; halogenated tyrosine aminotransferase; halogenated tyrosine transaminase
Systematic name: 3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase
Comments: A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-, 3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and triiodothyronine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-18-5
1.  Nakano, M. Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria. J. Biol. Chem. 242 (1967) 73–81. [PMID: 4381052]
2.  Nakano, M. and Danowski, T.S. Thyroid-hormone transaminase and oxidase in rat-kidney mitochondria. Biochim. Biophys. Acta 85 (1964) 18–28. [PMID: 14159298]
[EC created 1972 (EC created 1972, incorporated 1972)]

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