The Enzyme Database

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Accepted name: serine—pyruvate transaminase
Reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
For diagram of reaction, click here and for mechanism, click here
Other name(s): SPT; hydroxypyruvate:L-alanine transaminase
Systematic name: L-serine:pyruvate aminotransferase
Comments: A pyridoxal-phosphate protein. The liver enzyme may be identical with EC alanine-glyoxylate transaminase.
Links to other databases: BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-88-0
1.  Cheung, G.P., Rosenblum, I. and Sallach, H.J. Comparative studies of enzymes related to serine metabolism in higher plants. Plant Physiol. 43 (1968) 1813–1820. [PMID: 5699148]
2.  Kretovich, V.L. and Stepanovich, K.M. [The synthesis of serine from hydroxypyruvate in plants.] Dokl. Akad. Nauk S.S.S.R. 139 (1961) 488–490. (in Russian)
3.  Sallach, H.J. Formation of serine from hydroxypyruvate and L-alanine. J. Biol. Chem. 223 (1956) 1101–1108. [PMID: 13385257]
[EC created 1972]

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