| EC |
2.6.1.6 |
| Accepted name: |
leucine transaminase |
| Reaction: |
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate |
|
For diagram of reaction, click here, for diagram of leucine biosynthesis, click here and for diagram of mechanism, click here |
| Other name(s): |
L-leucine aminotransferase; leucine 2-oxoglutarate transaminase; leucine aminotransferase; leucine-α-ketoglutarate transaminase |
| Systematic name: |
L-leucine:2-oxoglutarate aminotransferase |
| Comments: |
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9030-37-9 |
| References: |
| 1. |
Aki, K., Ogawa, K. and Ichihara, A. Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver. Biochim. Biophys. Acta 159 (1968) 276–284. [DOI] [PMID: 4968655] |
| 2. |
Ikeda, T., Konishi, Y. and Ichihara, A. Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria. Biochim. Biophys. Acta 445 (1976) 622–631. [DOI] [PMID: 974100] |
|
| [EC 2.6.1.6 created 1961, modified 1982] |
| |
|
| |
|
Printable version