ExplorEnz: EC 2.7.1.1

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2.7.1.1

Accepted name:

hexokinase

Reaction:

ATP + D-hexose = ADP + D-hexose 6-phosphate

Other name(s):

hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase

Systematic name:

ATP:D-hexose 6-phosphotransferase

Comments:

D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-51-8

References:

1.	Bailey, K. and Webb, E.C. Purification of yeast hexokinase and its reaction with ββ′-dichlorodiethyl sulphide. Biochem. J. 42 (1948) 60–68. [PMID: 16748250]
2.	Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F. Isolation of hexokinase from baker's yeast. J. Gen. Physiol. 29 (1946) 379–391. [PMID: 19873467]
3.	Kunitz, M. and McDonald, M.R. Crystalline hexokinase (heterophosphatase). Method of isolation and properties. J. Gen. Physiol. 29 (1946) 393–412. [PMID: 19873468]
4.	Pollard-Knight, D. and Cornish-Bowden, A. Mechanism of liver glucokinase. Mol. Cell. Biochem. 44 (1982) 71–80. [PMID: 7048063]
5.	Ureta, T., Radojkovic, J., Lagos, R., Guixe, V. and Núñnez, L. Phylogenetic and ontogenetic studies of glucose phosphorylating isozymes of vertebrates. Arch. Biol. Med. Exp. 12 (1979) 587–604. [PMID: 233226]
6.	Cárdenas, M.L., Rabajille, E. and Niemeyer, H. Fructose: A good substrate for rat-liver 'glucokinase' (hexokinase D). Biochem. J. 222 (1984) 363–370. [PMID: 6477520]

[EC 2.7.1.1 created 1961]