| EC |
2.7.1.127 |
| Accepted name: |
inositol-trisphosphate 3-kinase |
| Reaction: |
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate |
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For diagram of myo-inositol-phosphate biosynthesis, click here |
| Other name(s): |
1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase |
| Systematic name: |
ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase |
| Comments: |
Activated by Ca2+. Three isoforms have been shown to exist [3]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 106283-10-7 |
| References: |
| 1. |
Hansen, C.A., Mah, S. and Williamson, J.R. Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver. J. Biol. Chem. 261 (1986) 8100–8103. [PMID: 3487541] |
| 2. |
Irvine, R.F., Letcher, A.J., Heslop, J.P. and Berridge, M.J. The inositol tris/tetrakisphosphate pathway - demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues. Nature 320 (1986) 631–634. [DOI] [PMID: 3010126] |
| 3. |
Irvine, R.F. and Schell, M.J. Back in the water - the return of the inositol phosphates. Nat. Rev. Mol. Cell. Biol. 2 (2001) 327–338. [DOI] [PMID: 11331907] |
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| [EC 2.7.1.127 created 1989, modified 2002] |
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