ExplorEnz: EC 2.7.1.137

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2.7.1.137

Accepted name:

phosphatidylinositol 3-kinase

Reaction:

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate

For diagram of 1-phosphatidyl-myo-inositol metabolism, click here

Glossary:

1-phosphatidyl-1D-myo-inositol = PtdIns
1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P

Other name(s):

1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase

Systematic name:

ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase

Comments:

One mammalian isoform is known.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 115926-52-8

References:

1.	Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332 (1988) 644–646. [DOI] [PMID: 2833705]
2.	Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D. Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70 (2001) 535–602. [DOI] [PMID: 11395417]

[EC 2.7.1.137 created 1992, modified 2002]