ExplorEnz: EC 2.7.1.148

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2.7.1.148

Accepted name:

4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase

Reaction:

ATP + 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol

For diagram of non-mevalonate terpenoid biosynthesis, click here

Other name(s):

CDP-ME kinase

Systematic name:

ATP:4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase

Comments:

The enzyme from Escherichia coli requires Mg²⁺ or Mn²⁺. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 263016-77-9

References:

1.	Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C.A., Fellermeier, M., Sagner, S., Zenk, M.H., Bacher, A. and Eisenreich, W. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erithritol. Proc. Natl. Acad. Sci. USA 97 (2000) 1062–1067. [DOI] [PMID: 10655484]
2.	Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T. and Seto, H. Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase. Tetrahedron Lett. 41 (2000) 2925–2928.

[EC 2.7.1.148 created 2001]