ExplorEnz: EC 2.7.1.149

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2.7.1.149

Accepted name:

1-phosphatidylinositol-5-phosphate 4-kinase

Reaction:

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here

Glossary:

1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P₂

Other name(s):

type II PIP kinase

Systematic name:

ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 247907-17-1

References:

1.	Rameh, L.E., Tolias, K.F., Duckworth, B.C. and Cantley, L.C. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature 390 (1997) 192–196. [DOI] [PMID: 9367159]

[EC 2.7.1.149 created 2002]