ExplorEnz: EC 2.7.1.159

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2.7.1.159

Accepted name:

inositol-1,3,4-trisphosphate 5/6-kinase

Reaction:

(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

Other name(s):

Ins(1,3,4)P₃ 5/6-kinase; inositol trisphosphate 5/6-kinase

Systematic name:

ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase

Comments:

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP₆). InsP₆ is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeasts do not have this enzyme, so produce InsP₆ from Ins(1,4,5)P₃ by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2]. The enzymes from animals and plants also have the activity of EC 2.7.1.134, inositol-tetrakisphosphate 1-kinase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 288307-53-9

References:

1.	Wilson, M.P. and Majerus, P.W. Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme. J. Biol. Chem. 271 (1996) 11904–11910. [DOI] [PMID: 8662638]
2.	Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W. The pathway for the production of inositol hexakisphosphate in human cells. J. Biol. Chem. 280 (2005) 1911–1920. [DOI] [PMID: 15531582]
3.	Miller, G.J., Wilson, M.P., Majerus, P.W. and Hurley, J.H. Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Mol. Cell. 18 (2005) 201–212. [DOI] [PMID: 15837423]

[EC 2.7.1.159 created 2006]