| EC |
2.7.1.163 |
| Accepted name: |
hygromycin B 4-O-kinase |
| Reaction: |
ATP + hygromycin B = ADP + 4-O-phosphohygromycin B |
| Other name(s): |
hygromycin-B kinase (ambiguous) |
| Systematic name: |
ATP:hygromycin-B 4-O-phosphotransferase |
| Comments: |
Phosphorylates the antibiotic hygromycin B. Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119; hygromycin-B 7′′-O-kinase) catalyses the formation of 7′′-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Rao, R.N., Allen, N.E., Hobbs, J.N., Jr., Alborn, W.E., Jr., Kirst, H.A. and Paschal, J.W. Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli. Antimicrob. Agents Chemother. 24 (1983) 689–695. [PMID: 6318654] |
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| [EC 2.7.1.163 created 2009] |
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