| EC |
2.7.1.177 |
| Accepted name: |
L-threonine kinase |
| Reaction: |
ATP + L-threonine = ADP + O-phospho-L-threonine |
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For diagram of corrin biosynthesis (part 6), click here |
| Other name(s): |
PduX |
| Systematic name: |
ATP:L-threonine O3-phosphotransferase |
| Comments: |
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Fan, C. and Bobik, T.A. The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis. J. Biol. Chem. 283 (2008) 11322–11329. [DOI] [PMID: 18308727] |
| 2. |
Fan, C., Fromm, H.J. and Bobik, T.A. Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica. J. Biol. Chem. 284 (2009) 20240–20248. [DOI] [PMID: 19509296] |
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| [EC 2.7.1.177 created 2012] |
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