| EC |
2.7.1.185 |
| Accepted name: |
mevalonate 3-kinase |
| Reaction: |
ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate |
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For diagram of the archaeal mevalonate pathway, click here |
| Other name(s): |
ATP:(R)-MVA 3-phosphotransferase |
| Systematic name: |
ATP:(R)-mevalonate 3-phosphotransferase |
| Comments: |
Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Vinokur, J.M., Korman, T.P., Cao, Z. and Bowie, J.U. Evidence of a novel mevalonate pathway in archaea. Biochemistry 53 (2014) 4161–4168. [DOI] [PMID: 24914732] |
| 2. |
Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. and Hemmi, H. (R)-Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J. Biol. Chem. 289 (2014) 15957–15967. [DOI] [PMID: 24755225] |
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| [EC 2.7.1.185 created 2014] |
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