The Enzyme Database

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EC 2.7.1.236     
Accepted name: NAD+ 3′-kinase
Reaction: ATP + NAD+ = ADP + 3′-NADP+
Glossary: 3′-NADP = nicotinamide adenine dinucleotide 3′-phosphate
Other name(s): AvrRxo1
Systematic name: ATP:NAD+ 3′-phosphotransferase
Comments: The enzyme, best characterized from the plant pathogenic bacterium Xanthomonas oryzae pv. oryzicola, is considered a bacterial type III effector. The product, 3′-NADP, is believed to enhance bacterial virulence on plants through manipulation of primary metabolic pathways. In vitro the enzyme is also active with nicotinate adenine dinucleotide (deamido-NAD).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Schuebel, F., Rocker, A., Edelmann, D., Schessner, J., Brieke, C. and Meinhart, A. 3′-NADP and 3′-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1. J. Biol. Chem. 291 (2016) 22868–22880. [DOI] [PMID: 27621317]
2.  Shidore, T., Broeckling, C.D., Kirkwood, J.S., Long, J.J., Miao, J., Zhao, B., Leach, J.E. and Triplett, L.R. The effector AvrRxo1 phosphorylates NAD in planta. PLoS Pathog. 13:e1006442 (2017). [DOI] [PMID: 28628666]
[EC 2.7.1.236 created 2022]
 
 


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