The Enzyme Database

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Accepted name: galactokinase
Reaction: ATP + α-D-galactose = ADP + α-D-galactose 1-phosphate
Other name(s): galactokinase (phosphorylating); ATP:D-galactose-1-phosphotransferase
Systematic name: ATP:α-D-galactose 1-phosphotransferase
Comments: Part of the Leloir pathway for galactose metabolism. The enzymes from mammals and from the bacterium Escherichia coli have no activity with N-acetyl-α-D-galactosamine [4-6].
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-53-9
1.  Cardini, C.E. and Leloir, L.F. Enzymic phosphorylation of galactosamine and galactose. Arch. Biochem. Biophys. 45 (1953) 55–64. [DOI] [PMID: 13058412]
2.  Neufeld, E.F., Feingold, D.S. and Hassid, W.Z. Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings. J. Biol. Chem. 235 (1960) 906–909. [PMID: 14426659]
3.  Wilkinson, J.F. The pathway of the adaptive fermentation of galactose by yeast. Biochem. J. 44 (1949) 460–467. [PMID: 16748546]
4.  Yang, J., Fu, X., Jia, Q., Shen, J., Biggins, J.B., Jiang, J., Zhao, J., Schmidt, J.J., Wang, P.G. and Thorson, J.S. Studies on the substrate specificity of Escherichia coli galactokinase. Org. Lett. 5 (2003) 2223–2226. [DOI] [PMID: 12816414]
5.  Timson, D.J. and Reece, R.J. Sugar recognition by human galactokinase. BMC Biochem. 4:16 (2003). [DOI] [PMID: 14596685]
6.  Thoden, J.B., Timson, D.J., Reece, R.J. and Holden, H.M. Molecular structure of human galactokinase: implications for type II galactosemia. J. Biol. Chem. 280 (2005) 9662–9670. [DOI] [PMID: 15590630]
[EC created 1961]

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