ExplorEnz: EC 2.7.1.72

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2.7.1.72

Accepted name:

streptomycin 6-kinase

Reaction:

ATP + streptomycin = ADP + streptomycin 6-phosphate

Other name(s):

streptidine kinase; SM 6-kinase; streptomycin 6-kinase (phosphorylating); streptidine kinase (phosphorylating); streptomycin 6-O-phosphotransferase; streptomycin 6-phosphotransferase

Systematic name:

ATP:streptomycin 6-phosphotransferase

Comments:

dATP can replace ATP; and dihydrostreptomycin, streptidine and
2-deoxystreptidine can act as acceptors.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37278-11-8

References:

1.	Walker, J.B. and Skorvaga, M. Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives. J. Biol. Chem. 248 (1973) 2435–2440. [PMID: 4121456]
2.	Walker, J.B. and Walker, M.S. Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate. Biochim. Biophys. Acta 148 (1967) 335–341. [DOI] [PMID: 6075410]

[EC 2.7.1.72 created 1972, modified 1976]