| EC |
2.7.1.74 |
| Accepted name: |
deoxycytidine kinase |
| Reaction: |
NTP + deoxycytidine = NDP + dCMP |
| Other name(s): |
deoxycytidine kinase (phosphorylating); 2′-deoxycytidine kinase; Ara-C kinase; arabinofuranosylcytosine kinase; deoxycytidine-cytidine kinase |
| Systematic name: |
NTP:deoxycytidine 5′-phosphotransferase |
| Comments: |
Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9039-45-6 |
| References: |
| 1. |
Durham, J.P. and Ives, D.H. Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme. J. Biol. Chem. 245 (1970) 2276–2284. [PMID: 5442271] |
| 2. |
Ives, D.H. and Durham, J.P. Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme. J. Biol. Chem. 245 (1970) 2285–2294. [PMID: 5462538] |
| 3. |
Kessel, D. Properties of deoxycytidine kinase partially purified from L1210 cells. J. Biol. Chem. 243 (1968) 4739–4744. [PMID: 5687717] |
| 4. |
Momparler, R.L. and Fischer, G.A. Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside. J. Biol. Chem. 243 (1968) 4298–4304. [PMID: 5684726] |
|
| [EC 2.7.1.74 created 1972] |
| |
|
| |
|
Printable version