| EC |
2.7.1.78 |
| Accepted name: |
polynucleotide 5′-hydroxyl-kinase |
| Reaction: |
ATP + 5′-dephospho-DNA = ADP + 5′-phospho-DNA |
| Other name(s): |
ATP:5′-dephosphopolynucleotide 5′-phosphatase; PNK; polynucleotide 5′-hydroxyl kinase (phosphorylating); 5′-hydroxyl polynucleotide kinase; 5′-hydroxyl polyribonucleotide kinase; 5′-hydroxyl RNA kinase; DNA 5′-hydroxyl kinase; DNA kinase; polynucleotide kinase; polynucleotide 5′-hydroxy-kinase |
| Systematic name: |
ATP:5′-dephosphopolynucleotide 5′-phosphotransferase |
| Comments: |
Also acts on 5′-dephospho-RNA 3′-mononucleotides. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37211-65-7 |
| References: |
| 1. |
Novogrodsky, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5′-hydroxyl termini. J. Biol. Chem. 241 (1966) 2923–2932. [PMID: 4287929] |
| 2. |
Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J. The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5′-hydroxyl polynucleotide kinase. J. Biol. Chem. 241 (1966) 2933–2943. [PMID: 4287930] |
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| [EC 2.7.1.78 created 1972] |
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