| EC |
2.7.1.8 |
| Accepted name: |
glucosamine kinase |
| Reaction: |
ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate |
| Glossary: |
D-glucosamine 6-phosphate = 2-amino-2-deoxy-D-glucose 6-phosphate |
| Other name(s): |
glucosamine kinase (phosphorylating); ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase; aminodeoxyglucose kinase; ATP:D-glucosamine phosphotransferase |
| Systematic name: |
ATP:D-glucosamine 6-phosphotransferase |
| Comments: |
The enzyme is specific for glucosamine and has only a minor activity with D-glucose. Two unrelated enzymes with this activity have been described. One type was studied in the bacterium Vibrio cholerae, where it participates in a chitin degradation pathway. The other type has been described from actinobacteria, where it is involved in the incorporation of environmental glucosamine into antibiotic biosynthesis pathways. cf. EC 2.7.1.147, ADP-specific glucose/glucosamine kinase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9031-90-7 |
| References: |
| 1. |
Bueding, E. and MacKinnon, J.A. Hexokinases of Schistosoma mansoni. J. Biol. Chem. 215 (1955) 495–506. [PMID: 13242546] |
| 2. |
Park, J.K., Wang, L.X. and Roseman, S. Isolation of a glucosamine-specific kinase, a unique enzyme of Vibrio cholerae. J. Biol. Chem. 277 (2002) 15573–15578. [DOI] [PMID: 11850417] |
| 3. |
Manso, J.A., Nunes-Costa, D., Macedo-Ribeiro, S., Empadinhas, N. and Pereira, P.J.B. Molecular fingerprints for a novel enzyme family in actinobacteria with glucosamine kinase activity. MBio 10:e00239-19 (2019). [PMID: 31088917] |
|
| [EC 2.7.1.8 created 1961, modified 2014, modified 2020] |
| |
|
| |
|
Printable version