| EC |
2.7.10.2 |
| Accepted name: |
non-specific protein-tyrosine kinase |
| Reaction: |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate |
| Other name(s): |
ABL; ABL1; ABL2; ABLL; ACK1; ACK2; AGMX1; ARG; ATK; ATP:protein-tyrosine O-phosphotransferase (ambiguous); BLK; Bmk; BMX; BRK; Bruton’s tyrosine kinase; Bsk; BTK; BTKL; CAKb; Cdgip; CHK; CSK; CTK; CYL; cytoplasmic protein tyrosine kinase; EMT; ETK; Fadk; FAK; FAK2; FER; Fert1/2; FES; FGR; focal adhesion kinase; FPS; FRK; FYN; HCK; HCTK; HYL; IMD1; ITK; IYK; JAK1; JAK2; JAK3; Janus kinase 1; Janus kinase 2; Janus kinase 3; JTK1; JTK9; L-JAK; LCK; LSK; LYN; MATK; Ntk; p60c-src protein tyrosine kinase; PKB; protein-tyrosine kinase (ambiguous); PSCTK; PSCTK1; PSCTK2; PSCTK4; PSCTK5; PTK2; PTK2B; PTK6; PYK2; RAFTK; RAK; Rlk; Sik; SLK; SRC; SRC2; SRK; SRM; SRMS; STD; SYK; SYN; Tck; TEC; TNK1; Tsk; TXK; TYK2; TYK3; YES1; YK2; ZAP70 |
| Systematic name: |
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) |
| Comments: |
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Robinson, D.R., Wu, Y.M. and Lin, S.F. The protein tyrosine kinase family of the human genome. Oncogene 19 (2000) 5548–5557. [DOI] [PMID: 11114734] |
| 2. |
Roskoski, R., Jr. Src protein-tyrosine kinase structure and regulation. Biochem. Biophys. Res. Commun. 324 (2004) 1155–1164. [DOI] [PMID: 15504335] |
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| [EC 2.7.10.2 created 1984 as EC 2.7.1.112, part transferred 2005 to EC 2.7.10.2] |
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