The Enzyme Database

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Accepted name: Ca2+/calmodulin-dependent protein kinase
Reaction: ATP + a protein = ADP + a phosphoprotein
Other name(s): ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase; Ca2+/calmodulin-dependent protein kinase 1; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase kinase; Ca2+/calmodulin-dependent protein kinase kinase β; calmodulin-dependent kinase II; CaM kinase; CaM kinase II; CAM PKII; CaM-regulated serine/threonine kinase; CaMKI; CaMKII; CaMKIV; CaMKKα; CaMKKβ; microtubule-associated protein 2 kinase; STK20
Systematic name: ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Comments: Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC (myosin-light-chain kinase) or EC (tau-protein kinase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141467-21-2
1.  Adlersberg, M., Liu, K.P., Hsiung, S.C., Ehrlich, Y. and Tamir, H. A Ca2+-dependent protein kinase activity associated with serotonin binding protein. J. Neurochem. 49 (1987) 1105–1115. [DOI] [PMID: 3040904]
2.  Baudier, J. and Cole, R.D. Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids. J. Biol. Chem. 262 (1987) 17577–17583. [PMID: 3121601]
3.  Schulman, H., Kuret, J., Jefferson, A.B., Nose, P.S. and Spitzer, K.H. Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues. Biochemistry 24 (1985) 5320–5327. [PMID: 4074698]
4.  Anderson, K.A., Means, R.L., Huang, Q.H., Kemp, B.E., Goldstein, E.G., Selbert, M.A., Edelman, A.M., Fremeau, R.T. and Means, A.R. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J. Biol. Chem. 273 (1998) 31880–31889. [DOI] [PMID: 9822657]
5.  Matsushita, M. and Nairn, A.C. Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. J. Biol. Chem. 273 (1998) 21473–21481. [DOI] [PMID: 9705275]
6.  Ohmstede, C.A., Jensen, K.F. and Sahyoun, N.E. Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase. J. Biol. Chem. 264 (1989) 5866–5875. [PMID: 2538431]
7.  Rieker, J.P., Swanljung-Collins, H. and Collins, J.H. Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border. J. Biol. Chem. 262 (1987) 15262–15268. [PMID: 2822719]
8.  Iwasa, T., Inoue, N., Fukunaga, K., Isobe, T., Okuyama, T. and Miyamoto, E. Purification and characterization of a multifunctional calmodulin-dependent protein kinase from canine myocardial cytosol. Arch. Biochem. Biophys. 248 (1986) 21–29. [DOI] [PMID: 3089163]
9.  Gomes, A.V., Barnes, J.A. and Vogel, H.J. Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch. Biochem. Biophys. 379 (2000) 28–36. [DOI] [PMID: 10864438]
10.  Mal, T.K., Skrynnikov, N.R., Yap, K.L., Kay, L.E. and Ikura, M. Detecting protein kinase recognition modes of calmodulin by residual dipolar couplings in solution NMR. Biochemistry 41 (2002) 12899–12906. [DOI] [PMID: 12390014]
11.  Ngai, P.K. and Walsh, M.P. Inhibition of smooth muscle actin-activated myosin Mg2+-ATPase activity by caldesmon. J. Biol. Chem. 259 (1984) 13656–13659. [PMID: 6150036]
12.  Ikebe, M., Reardon, S., Scott-Woo, G.C., Zhou, Z. and Koda, Y. Purification and characterization of calmodulin-dependent multifunctional protein kinase from smooth muscle: isolation of caldesmon kinase. Biochemistry 29 (1990) 11242–11248. [PMID: 2176896]
[EC created 1989 as EC, transferred 2005 to EC (EC incorporated 2005)]

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