The Enzyme Database

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Accepted name: cyclin-dependent kinase
Reaction: ATP + a protein = ADP + a phosphoprotein
Other name(s): Bur1; Bur1 Cdk; Cak1; Cak1p; cdc2; cdc2 kinase; Cdc28p; CDK; cdk-activating kinase; Cdk-activating protein kinase; cdk1; cdk2; Cdk2; cdk3; cdk4; cdk5; cdk6; cdk7; cdk8; cdk9; cyclin A-activated cdc2; cyclin A-activated cdk2; cyclin D-cdk6 kinase; cyclin D-dependent kinase; cyclin E kinase; cyclin-A associated kinase; cyclin-dependent kinase 6; cyclin-dependent kinase-2; cyclin-dependent kinase-4; cyclin-dependent protein kinase activating kinase; cyk; D-type cyclin kinase; nclk; neuronal cdc2-like kinase; PCTAIRE-1; STK25
Systematic name: ATP:cyclin phosphotransferase
Comments: Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Johnson, D.G. and Walker, C.L. Cyclins and cell cycle checkpoints. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 295–312. [DOI] [PMID: 10331086]
2.  Pan, Z.Q., Amin, A. and Hurwitz, J. Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. J. Biol. Chem. 268 (1993) 20443–20451. [PMID: 8397207]
3.  Yee, A., Wu, L., Liu, L., Kobayashi, R., Xiong, Y. and Hall, F.L. Biochemical characterization of the human cyclin-dependent protein kinase activating kinase. Identification of p35 as a novel regulatory subunit. J. Biol. Chem. 271 (1996) 471–477. [DOI] [PMID: 8550604]
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