| EC |
2.7.11.23 |
| Accepted name: |
[RNA-polymerase]-subunit kinase |
| Reaction: |
ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase] |
| Other name(s): |
CTD kinase; STK9 |
| Systematic name: |
ATP:[DNA-directed RNA polymerase] phosphotransferase |
| Comments: |
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 122097-00-1 |
| References: |
| 1. |
Lee, J.M. and Greenleaf, A.L. A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II. Proc. Natl. Acad. Sci. USA 86 (1989) 3624–3628. [DOI] [PMID: 2657724] |
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| [EC 2.7.11.23 created 1992 as EC 2.7.1.141, transferred 2005 to EC 2.7.11.23] |
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