The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: low-density-lipoprotein receptor kinase
Reaction: ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
Other name(s): ATP:low-density-lipoprotein-L-serine O-phosphotransferase; LDL receptor kinase; [low-density-lipoprotein] kinase; low-density lipoprotein kinase; low-density-lipoprotein receptor kinase (phosphorylating); STK7
Systematic name: ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase
Comments: Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 107445-00-1
1.  Kishimoto, A., Brown, M.S., Slaughter, C.A. and Goldstein, J.L. Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II. J. Biol. Chem. 262 (1987) 1344–1351. [PMID: 3100530]
2.  Kishimoto, A., Goldstein, J.L. and Brown, M.S. Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein. J. Biol. Chem. 262 (1987) 9367–9373. [PMID: 3597414]
[EC created 1990 as EC, transferred 2005 to EC]

Data © 2001–2023 IUBMB
Web site © 2005–2023 Andrew McDonald