The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: receptor protein serine/threonine kinase
Reaction: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Other name(s): activin receptor kinase; receptor type I serine/threonine protein kinase; receptor type II serine/threonine protein kinase; STK13; TGF-β kinase; receptor serine/threonine protein kinase
Systematic name: ATP:[receptor-protein] phosphotransferase
Comments: The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Wrana, J.L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. Mechanism of activation of the TGF-β receptor. Nature 370 (1994) 341–347. [DOI] [PMID: 8047140]
2.  Massagué, J. and Chen, Y.G. Controlling TGF-β signaling. Gene 14 (2000) 627–644. [PMID: 10733523]
3.  de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B. and Lechleider, R.J. Characterization of functional domains within Smad4/DPC4. J. Biol. Chem. 272 (1997) 13690–13696. [DOI] [PMID: 9153220]
[EC created 2005 (EC part-incorporated 2005)]

Data © 2001–2024 IUBMB
Web site © 2005–2024 Andrew McDonald