The Enzyme Database

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Accepted name: [tyrosine 3-monooxygenase] kinase
Reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
Other name(s): pheochromocytoma tyrosine hydroxylase-associated kinase; STK4; tyrosine 3-monooxygenase kinase (phosphorylating)
Systematic name: ATP:[tyrosine-3-monooxygenase] phosphotransferase
Comments: The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC, tyrosine 3-monooxygenase, by phosphorylation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 103537-12-8
1.  Pigeon, D., Drissi-Daoudi, R., Gros, F. and Thibault, J. Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase. C. R. Acad. Sci. III 302 (1986) 435–438. [PMID: 2872947]
2.  Pigeon, D., Ferrara, P., Gros, F. and Thibault, J. Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase. J. Biol. Chem. 262 (1987) 6155–6158. [PMID: 2883182]
[EC created 1989 as EC, transferred 2005 to EC]

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