| EC |
2.7.11.8 |
| Accepted name: |
Fas-activated serine/threonine kinase |
| Reaction: |
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein] |
| Other name(s): |
FAST; FASTK; STK10 |
| Systematic name: |
ATP:[Fas-activated serine/threonine protein] phosphotransferase |
| Comments: |
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 170347-50-9 |
| References: |
| 1. |
Tian, Q., Taupin, J., Elledge, S., Robertson, M. and Anderson, P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J. Exp. Med. 182 (1995) 865–874. [PMID: 7544399] |
| 2. |
Li, W., Simarro, M., Kedersha, N. and Anderson, P. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Mol. Cell. Biol. 24 (2004) 10718–10732. [DOI] [PMID: 15572676] |
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| [EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)] |
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