The Enzyme Database

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Accepted name: Fas-activated serine/threonine kinase
Reaction: ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Other name(s): FAST; FASTK; STK10
Systematic name: ATP:[Fas-activated serine/threonine protein] phosphotransferase
Comments: This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 170347-50-9
1.  Tian, Q., Taupin, J., Elledge, S., Robertson, M. and Anderson, P. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J. Exp. Med. 182 (1995) 865–874. [PMID: 7544399]
2.  Li, W., Simarro, M., Kedersha, N. and Anderson, P. FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression. Mol. Cell. Biol. 24 (2004) 10718–10732. [DOI] [PMID: 15572676]
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