The Enzyme Database

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Accepted name: Goodpasture-antigen-binding protein kinase
Reaction: ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]
Other name(s): GPBPK; GPBP kinase; STK11; Goodpasture antigen-binding protein kinase
Systematic name: ATP:[Goodpasture antigen-binding protein] phosphotransferase
Comments: This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the α3 chain of collagen IV and is involved in autoimmune disease.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 230316-19-5
1.  Raya, A., Revert, F., Navarro, S. and Saus, J. Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human Goodpasture antigen. J. Biol. Chem. 274 (1999) 12642–12649. [DOI] [PMID: 10212244]
2.  Raya, A., Revert-Ros, F., Martinez-Martinez, P., Navarro, S., Rosello, E., Vieites, B., Granero, F., Forteza, J. and Saus, J. Goodpasture antigen-binding protein, the kinase that phosphorylates the Goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis. J. Biol. Chem. 275 (2000) 40392–40399. [DOI] [PMID: 11007769]
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