ExplorEnz: EC 2.7.12.1

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2.7.12.1

Accepted name:

dual-specificity kinase

Reaction:

ATP + a protein = ADP + a phosphoprotein

Other name(s):

ADK1; Arabidopsis dual specificity kinase 1; CLK1; dDYRK2; Mps1p

Systematic name:

ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)

Comments:

This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Ali, N., Halfter, U. and Chua, N.H. Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine. J. Biol. Chem. 269 (1994) 31626–31629. [PMID: 7527390]
2.	Lauze, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A.R. and Winey, M. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. EMBO J. 14 (1995) 1655–1663. [PMID: 7737118]
3.	Menegay, H.J., Myers, M.P., Moeslein, F.M. and Landreth, G.E. Biochemical characterization and localization of the dual specificity kinase CLK1. J. Cell Sci. 113 (2000) 3241–3253. [PMID: 10954422]
4.	Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K. and Cleghon, V. dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Biochem. J. 374 (2003) 381–391. [DOI] [PMID: 12786602]

[EC 2.7.12.1 created 2005 (EC 2.7.1.37 part-incorporated 2005)]