ExplorEnz: EC 2.7.14.1

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2.7.14.1

Accepted name:

protein arginine kinase

Reaction:

ATP + a [protein]-L-arginine = ADP + a [protein]-N^ω-phospho-L-arginine

Other name(s):

McsB

Systematic name:

ATP:[protein]-L-arginine N^ω-phosphotransferase

Comments:

The enzyme, characterized from Gram-positive bacteria, is involved in the regulation of the bacterial stress response.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Fuhrmann, J., Schmidt, A., Spiess, S., Lehner, A., Turgay, K., Mechtler, K., Charpentier, E. and Clausen, T. McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science 324 (2009) 1323–1327. [DOI] [PMID: 19498169]
2.	Elsholz, A.K., Turgay, K., Michalik, S., Hessling, B., Gronau, K., Oertel, D., Mader, U., Bernhardt, J., Becher, D., Hecker, M. and Gerth, U. Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 109 (2012) 7451–7456. [DOI] [PMID: 22517742]
3.	Schmidt, A., Trentini, D.B., Spiess, S., Fuhrmann, J., Ammerer, G., Mechtler, K. and Clausen, T. Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response. Mol. Cell. Proteomics 13 (2014) 537–550. [DOI] [PMID: 24263382]

[EC 2.7.14.1 created 2014]