| EC |
2.7.3.9 |
| Accepted name: |
phosphoenolpyruvate—protein phosphotransferase |
| Reaction: |
phosphoenolpyruvate + protein histidine = pyruvate + protein Nπ-phospho-L-histidine |
| Other name(s): |
phosphoenolpyruvate sugar phosphotransferase enzyme I; phosphopyruvate-protein factor phosphotransferase; phosphopyruvate-protein phosphotransferase; sugar-PEP phosphotransferase enzyme I; phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase |
| Systematic name: |
phosphoenolpyruvate:protein-L-histidine Nπ-phosphotransferase |
| Comments: |
Enzyme I of the phosphotransferase system (cf. EC 2.7.1.191, EC 2.7.1.192, EC 2.7.1.193, EC 2.7.1.194, EC 2.7.1.195, EC 2.7.1.196, EC 2.7.1.197, EC 2.7.1.198, EC 2.7.1.199, EC 2.7.1.200, EC 2.7.1.201, EC 2.7.1.202, EC 2.7.1.203, EC 2.7.1.204, EC 2.7.1.205, EC 2.7.1.206, EC 2.7.1.207 and EC 2.7.1.208). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC 2.7.9.2 pyruvate, water dikinase, is part of the mechanism of that enzyme. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37278-17-4 |
| References: |
| 1. |
Postma, P.W. and Roseman, S. The bacterial phosphoenolpyruvate: sugar phosphotransferase system. Biochim. Biophys. Acta 457 (1976) 213–257. [PMID: 187249] |
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| [EC 2.7.3.9 created 1972] |
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