| EC |
2.7.7.3 |
| Accepted name: |
pantetheine-phosphate adenylyltransferase |
| Reaction: |
ATP + pantetheine 4′-phosphate = diphosphate + 3′-dephospho-CoA |
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For diagram of the late stages of CoA biosynthesis, click here |
| Other name(s): |
dephospho-CoA pyrophosphorylase; pantetheine phosphate adenylyltransferase; dephospho-coenzyme A pyrophosphorylase; 3′-dephospho-CoA pyrophosphorylase |
| Systematic name: |
ATP:pantetheine-4′-phosphate adenylyltransferase |
| Comments: |
The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC 2.3.1.157, glucosamine-1-phosphate N-acetyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9026-99-7 |
| References: |
| 1. |
Hoagland, M.B. and Novelli, G.D. Biosynthesis of coenzyme A from phosphopantetheine and pantetheine from pantothenate. J. Biol. Chem. 207 (1954) 767–773. [PMID: 13163064] |
| 2. |
Novelli, G.D. Enzymatic synthesis and structure of CoA. Fed. Proc. 12 (1953) 675–682. [PMID: 13107738] |
| 3. |
Martin, D.P. and Drueckhammer, D.G. Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase. Biochem. Biophys. Res. Commun. 192 (1993) 1155–1161. [DOI] [PMID: 8389542] |
| 4. |
Geerlof, A., Lewendon, A. and Shaw, W.V. Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. J. Biol. Chem. 274 (1999) 27105–27111. [DOI] [PMID: 10480925] |
| 5. |
Izard, T., Geerlof, A., Lewendon, A. and Barker, J.J. Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia
coli. Acta Crystallogr. D Biol. Crystallogr. 55 (1999) 1226–1228. [PMID: 10329792] |
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| [EC 2.7.7.3 created 1961, modified 2002] |
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