ExplorEnz: EC 2.7.7.31

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2.7.7.31

Accepted name:

DNA nucleotidylexotransferase

Reaction:

2′-deoxyribonucleoside 5′-triphosphate + DNA_n = diphosphate + DNA_n+1

Other name(s):

terminal deoxyribonucleotidyltransferase; terminal addition enzyme; addase; deoxynucleotidyl terminal transferase; deoxyribonucleic acid nucleotidyltransferase; deoxyribonucleic nucleotidyltransferase; terminal deoxynucleotide transferase; TdT

Systematic name:

2′-deoxyribonucleoside-5′-triphosphate:DNA deoxynucleotidylexotransferase

Comments:

Catalyses template-independent extension of the 3′- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2′-deoxyribo-.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9027-67-2

References:

1.	Bollum, F.J. Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase. J. Biol. Chem. 246 (1971) 909–916. [PMID: 5543689]
2.	Gottesman, M.E. and Canellakis, E.S. The terminal nucleotidyltransferases of calf thymus nuclei. J. Biol. Chem. 241 (1966) 4339–4352. [DOI] [PMID: 4288534]
3.	Krakow, J.S., Coutsogeorgopoulos, C. and Canellakis, E.S. Studies on the incorporation of deoxyribonucleic acid. Biochim. Biophys. Acta 55 (1962) 639–650. [DOI] [PMID: 14459258]

[EC 2.7.7.31 created 1972]