| EC |
2.7.7.56 |
| Accepted name: |
tRNA nucleotidyltransferase |
| Reaction: |
tRNAn+1 + phosphate = tRNAn + a nucleoside diphosphate |
| Other name(s): |
phosphate-dependent exonuclease; RNase PH; ribonuclease PH |
| Systematic name: |
tRNA:phosphate nucleotidyltransferase |
| Comments: |
Brings about the final exonucleolytic trimming of the 3′-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3′-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 116412-36-3 |
| References: |
| 1. |
Cudny, H. and Deutscher, M.P. 3′ processing of tRNA precursors in ribonuclease-deficient Escherichia coli. Development and characterization of an in vitro processing system and evidence for a phosphate requirement. J. Biol. Chem. 263 (1988) 1518–1523. [PMID: 3275667] |
| 2. |
Deutscher, M.P., Marshall, G.T. and Cudny, H. RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase. Proc. Natl. Acad. Sci. USA 85 (1988) 4710–4714. [DOI] [PMID: 2455297] |
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| [EC 2.7.7.56 created 1992] |
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