| EC |
2.7.7.75 |
| Accepted name: |
molybdopterin adenylyltransferase |
| Reaction: |
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin |
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For diagram of MoCo biosynthesis, click here |
| Glossary: |
molybdopterin = H2Dtpp-mP = [(5aR,8R,9aR)-2-amino-4-oxo-6,7-bis(sulfanyl)-4,5,5a,8,9a,10-hexahydro-1H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogen phosphate |
| Other name(s): |
MogA; Cnx1 (ambiguous) |
| Systematic name: |
ATP:molybdopterin adenylyltransferase |
| Comments: |
Catalyses the activation of molybdopterin for molybdenum insertion. In eukaryotes, this reaction is catalysed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). The reaction requires a divalent cation such as Mg2+ or Mn2+. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Nichols, J.D. and Rajagopalan, K.V. In vitro molybdenum ligation to molybdopterin using purified components. J. Biol. Chem. 280 (2005) 7817–7822. [DOI] [PMID: 15632135] |
| 2. |
Kuper, J., Palmer, T., Mendel, R.R. and Schwarz, G. Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization. Proc. Natl. Acad. Sci. USA 97 (2000) 6475–6480. [DOI] [PMID: 10823911] |
| 3. |
Llamas, A., Mendel, R.R. and Schwarz, G. Synthesis of adenylated molybdopterin: an essential step for molybdenum insertion. J. Biol. Chem. 279 (2004) 55241–55246. [DOI] [PMID: 15504727] |
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| [EC 2.7.7.75 created 2011] |
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