EC |
2.7.7.77 |
Accepted name: |
molybdenum cofactor guanylyltransferase |
Reaction: |
GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor |
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For diagram of MoCo biosynthesis, click here |
Glossary: |
molybdenum cofactor = MoCo = MoO2(OH)Dtpp-mP = {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-bis(sulfanyl-κS)-1,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)molybdate |
Other name(s): |
MobA; MoCo guanylyltransferase |
Systematic name: |
GTP:molybdenum cofactor guanylyltransferase |
Comments: |
Catalyses the guanylation of the molybdenum cofactor. This modification occurs only in prokaryotes. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Lake, M.W., Temple, C.A., Rajagopalan, K.V. and Schindelin, H. The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. J. Biol. Chem. 275 (2000) 40211–40217. [DOI] [PMID: 10978347] |
2. |
Temple, C.A. and Rajagopalan, K.V. Mechanism of assembly of the bis(molybdopterin guanine dinucleotide)molybdenum cofactor in Rhodobacter sphaeroides dimethyl sulfoxide reductase. J. Biol. Chem. 275 (2000) 40202–40210. [DOI] [PMID: 10978348] |
3. |
Guse, A., Stevenson, C.E., Kuper, J., Buchanan, G., Schwarz, G., Giordano, G., Magalon, A., Mendel, R.R., Lawson, D.M. and Palmer, T. Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA. J. Biol. Chem. 278 (2003) 25302–25307. [DOI] [PMID: 12719427] |
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[EC 2.7.7.77 created 2011] |
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