EC |
2.7.7.8 |
Accepted name: |
polyribonucleotide nucleotidyltransferase |
Reaction: |
RNAn+1 + phosphate = RNAn + a nucleoside diphosphate |
Other name(s): |
polynucleotide phosphorylase; PNPase (ambiguous); nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide phosphorylase |
Systematic name: |
polyribonucleotide:phosphate nucleotidyltransferase |
Comments: |
ADP, IDP, GDP, UDP and CDP can act as donors. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9014-12-4 |
References: |
1. |
Hakim, A.A. Synthetic activity of polynucleotide phosphorylase from sperm. Nature 183 (1959) 334. [PMID: 13632712] |
2. |
Littauer, U.Z. and Kornberg, A. Reversible synthesis of polyribonucleotides with an enzyme from Escherichia coli. J. Biol. Chem. 226 (1957) 1077–1092. [PMID: 13438894] |
3. |
Ochoa, S. and Mii, S. Enzymatic synthesis of polynucleotides. IV. Purification and properties of polynucleotide phosphorylase from Azotobacter vinelandii. J. Biol. Chem. 236 (1961) 3303–3311. [PMID: 14481058] |
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[EC 2.7.7.8 created 1961] |
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