| EC |
2.7.7.82 |
| Accepted name: |
CMP-N,N′-diacetyllegionaminic acid synthase |
| Reaction: |
CTP + N,N′-diacetyllegionaminate = CMP-N,N′-diacetyllegionaminate + diphosphate |
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For diagram of legionaminic acid biosynthesis, click here |
| Glossary: |
legionaminate = 5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonate |
| Other name(s): |
CMP-N,N′-diacetyllegionaminic acid synthetase; neuA (gene name); legF (gene name) |
| Systematic name: |
CTP:N,N′-diacetyllegionaminate cytidylyltransferase |
| Comments: |
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila. Biochemistry 47 (2008) 3272–3282. [DOI] [PMID: 18275154] |
| 2. |
Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. Glycobiology 19 (2009) 715–725. [DOI] [PMID: 19282391] |
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| [EC 2.7.7.82 created 2012] |
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