EC |
2.7.7.91 |
Accepted name: |
valienol-1-phosphate guanylyltransferase |
Reaction: |
GTP + valienol 1-phosphate = diphosphate + GDP-valienol |
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For diagram of validamycin biosynthesis, click here |
Glossary: |
valienol 1-phosphate = (1S,4R,5S,6R)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl phosphate |
Other name(s): |
vldB (gene name) |
Systematic name: |
GTP:valienol 1-phosphate guanylyltransferase |
Comments: |
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Yang, J., Xu, H., Zhang, Y., Bai, L., Deng, Z. and Mahmud, T. Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis. Org. Biomol. Chem. 9 (2011) 438–449. [DOI] [PMID: 20981366] |
2. |
Asamizu, S., Yang, J., Almabruk, K.H. and Mahmud, T. Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis. J. Am. Chem. Soc. 133 (2011) 12124–12135. [DOI] [PMID: 21766819] |
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[EC 2.7.7.91 created 2016] |
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